Lipodisq® technology represents a significant step forward in skincare science, addressing the key limitations of active agent stability and topical penetration whilst enhancing performance, efficacy and user experience. These attributes make Lipodisq® encapsulated Personal Care actives a preferred choice for individuals seeking effective, gentle, and scientifically advanced skincare solutions.
Inspired by the structure of naturally occurring High Density Lipoprotein (HDL) endogenous in the human body, Lipodisq® are biodegradable self-assembling nano structures, 10-40nm in size. Composed of naturally sourced phospholipid (Soy, Non-GMO) in the form of a phospholipid bilayer, stabilised by conventional surfactant structures, Lipodisq® technology is able to solubilise hydrophobic/lipophilic and amphiphilic active agents. Encapsulation within Lipodisq® renders the active agent water soluble, enhances agent stability, increases topical penetration and increases the scope of formulation formats available to the formulator.
Lipodisq® encapsulated active agents are available in two formats for use in the personal care industry. Our most versatile Standard Grade solutions are composed of nano structures assembled from Soy Phospholipids (non-GMO) and Polysorbate 20 (RSPO, MBAL). Our Green Grade solutions are Polysorbate free, utilising Sucrose Ester surfactants of natural origin, enhancing Biodegradability and Naturality profile.
The small size of Lipodisq® particles enables them to penetrate the upper layer of the epidermis, the stratum corneum, while their oily hydrophobic core enables a high loading capacity for oil soluble agents, consequently they have a far greater potential for delivering significant amounts of active agents, as compared to much larger particle systems such as liposomes/niosomes.
In vivo study: Lipodisq® formulation containing a marker dye is applied to the outer layer of the skin for 20 minutes, the skin is washed and adhesive tape used to repeatedly strip layers of stratum corneum, the dye removed on each strip is then analysed spectrophotometrically using a near-infrared technique to assess the presence of the marker dye. Results: Lipodisq® formulation facilitates penetration of the dye to the lower layers of the stratum corneum, effectively overcoming the barrier function of the skin.
Whilst encapsulating hydrophobic or amphoteric active agents within its phospholipid membrane and rendering them water soluble, Lipodisq® constructs also protect the active agent from oxidation and degradation. Lipodisq® formulated actives can exhibit superior stability, in concentrated formats as well as finished products, vs conventional product offerings. Providing both the consumer and product manufacturers with stable and efficacious products for the duration of their use.
Lipodisq® Retinal PE Solution
After >365 days storage at room temperature, 93.80% Retinal content retained within Lipodisq® sample (UV-Vis Spectrophotometer measurement @ λ 380nm) compared to 40.00% Retinal content retained within a conventional formulation format. Particle stability and size characteristics remain unchanged.
Product | INCI | Key Features |
Lipodisq® Retinol PE Solution | Aqua, Polysorbate 20, Retinol, Lecithin, Phenoxyethanol, Ethylhexylglycerin, BHT, BHA | Anti-ageing, skin lightening / brightening, stimulates collagen production, thickens dermal layer and has a plumping effect. |
Lipodisq® Green Retinol Solution | Aqua, Sucrose ester, Bioflavonoids, Retinol, Lecithin, Undecane, Pentyleneglycol, Capry-lyl glycol, Tridecane, Tocopherol | Anti-ageing, skin lightening / brightening, stimulates collagen production, thickens dermal layer and has a plumping effect. Fully biodegradable, natural origin Lipodisq® components. 99% Naturality Score! |
Lipodisq® Retinal PE Solution | Aqua, Polysorbate 20, Retinal, Lecithin, Phenoxyethanol, Ethylhexylglycerin | Anti-ageing, skin lightening / brightening, stimulates collagen production, thickens dermal layer and has a plumping effect. Just one step metabolic conversion needed to form retinoic acid within the skin! |
Product | INCI | Key Features |
Lipodisq® Ascorbyl Palmitate PE Solution | Aqua, Polysorbate 20, Lecithin, Ascorbyl Palmitate, Phenoxyethanol, Ethylhexyl-glycerin | Stimulates collagen production, anti-oxidant and radical scavenging, with anti-ageing, anti-pigmenting effect, reverses skin damage and protects against environmental aggressors. |
Lipodisq® Hyaluronate PE Solution | Aqua, Sodium hyaluronate, Polysorbate 20, Lecithin, Phenoxyethanol, Ethylhex-ylglycerin | Sodium Hyaluronate: Selected low molecular weight (<10,000Da) grade to provide efficient moisturising and hydration, plumping, anti-aging and skin restructuring effects. |
Lipodisq® Skin Brightener PE Solution | Aqua, Niacinamide, Sodium ascorbyl phosphate, Polysorbate 20, Lecithin, Phenoxyethanol, Ethylhexylglycerin | Promote even skin tone and reverses age-spot related pigmentation. Stabilised Vitamin C providing powerful anti-oxidant activity. |
Lipodisq® Escin SAP PE Solution | Aqua, Polysorbate 20, Extract of Aescu-lus hippocastanum, Sodium ascorbyl phosphate, Lecithin, Phenoxyethanol, Ethylhexylglycerin | Vasoconstrictor and brightening properties to address skin surface redness, promote micro-circulation and lymphatic drainage under eye, combat cellulite in the leg/thigh. |
Lipodisq® Niacinamide PE Solution | Aqua, Niacinamide, Polysorbate 20, Lecithin, Phenoxyethanol, Ethylhexyl-glycerin | Promote even skin tone and reverses age-spot related pigmentation. |
Lipodisq® Oxyresveratrol PE Solution | Aqua, Polysorbate 20, Dipotassium Glycyrrhizate, Lecithin, Oxyresveratrol, Phenoxyethanol, Ethylhexylglycerin | Skin brightening / lightening properties via inhibition of tyrosinase. Potent anti-oxidant for ROS scavenging, anti-ageing, skin soothing and anti-inflammatory activity. |
Lipodisq® Tranexamic Acid PE Solution | Aqua, Tranexamic Acid, Polysorbate 20, Lecithin, Phenoxyethanol, Dipotassium Glycyrrhizate, Disodium EDTA, Ethylhex-ylglycerin | Skin-brightening agent, improve uneven skin tone and reduce the appearance of dark spots, sun spots, and acne scars. |
Product | INCI | Key Features |
Lipodisq® Green Retinol Solution | Aqua, Sucrose ester, Bioflavonoids, Retinol, Lecithin, Undecane, Pentylene glycol, Caprylyl glycol, Tridecane, Tocopherol | Anti-ageing, skin lightening / brightening, stimulates collagen production, thickens dermal layer and has a plumping effect. |
Lipodisq® Green Hyaluronate Solution | Aqua, Sodium hyaluronate, Sucrose ester, Lecithin, Pentylene glycol, Caprylyl glycol, Bioflavonoids | Sodium Hyaluronate: Selected low molecular weight (<10,000Da) grade to provide efficient moisturising and hydra-tion, plumping, anti-aging and skin restructuring effects. |
Lipodisq® Green Niacinamide Solution | Aqua, Niacinamide, Sucrose ester, Lecithin, Pentylene glycol, Caprylyl glycol, Bioflavo-noids | Promote even skin tone and reverses age-spot related pigmentation. |
Lipodisq® Green Oxyresveratrol Solution | Aqua, Sucrose ester, Dipotassium Glycyr-rhizate, Lecithin, Oxyresveratrol, Pentylene glycol, Caprylyl glycol, Bioflavonoids | Skin brightening / lightening properties via inhibition of tyrosinase. Potent anti- oxidant for ROS scavenging, anti-ageing, skin soothing and anti-inflammatory activity. |
Lipodisq® technology is covered by one or more of the following patents owned by Malvern Cosmeceutics Limited:
AU 2006253886
CA 2,611,144
CN ZL200680018957.2
EP 1890675
GB 2426703
JP5142989
IN 261468
US 8623414
WO/2021/005340A1 pending
AU2007327054
CN ZL200780044148.3
GB2464393
JP6567575
JP5142989
SA2009/02939
Contact us for further information or to discuss your personal care project.
To aid your product development and access to Lipodisq® Personal Care Solutions, Lipodisq® products are also available from our commercial distribution partners:
UK & Ireland
Japan
Vietnam
South Korea
Please contact us to enquire for your region/territory by filling in the enquiry form.
Discovery
Pre-clinical
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